In-silico studies, synthesis, and pharmacological screening of novel multitarget diphenylpyrazole scaffold as EGFR/BRAF and cyclooxygenase-2 inhibitors.

ABSTRACT: Multi-targeting drug design has become a prevalent attitude in exploring effective potent anticancer agents. In this regard, cyclooxygenase II (COX 2), tubulin, and focal adhesion kinase (FAK) are emerging as highly effective targets in the battle against cancer. Pyrazoles AS-(1-16) were prepared, and their structures were confirmed using NMR and IR tools. The designed compounds AS-(1-16) were investigated for their COXs inhibition and antiproliferative activities. Compounds AS-1, 2, and 14 showed high activities as COX inhibitors and antiproliferatives. Compounds AS-1, 2, and 14 were further investigated for their inhibitory activities towards tubulin polymerization, FAK, EGFR, BRAF and AS-14 showed the highest pronounced activities. AS-14 was subjected to cell cycle and showed activity a

SUBMITTER: Abdelgawad MA 

PROVIDER: S-EPMC12808126 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature