Pulmonary toxicity of polymethyl methacrylate nanoplastics via intratracheal intubation in mice.

ABSTRACT: Plastics, ubiquitous in daily life and industry, are released into the environment in substantial quantities. Instead of complete biodegradation, plastic waste fragments into smaller particles, accumulating as nanoplastics (NPs; < 1 μm). Humans are exposed to NPs through inhalation and ingestion of contaminated water and food, which can induce cytotoxicity through physical and chemical pathways. Polymethyl methacrylate (PMMA), commonly used in implants and artificial bones, has been identified in human lungs and associated with pulmonary embolism. While PMMA NP toxicity has been reported in vitro, their in vivo effects, as well as the underlying mechanism, remain poorly understood. In this study, we investigated the pulmonary effects of inhaled PMMA NPs in mice. Mice received 20 or 100 μg

SUBMITTER: Youn C 

PROVIDER: S-EPMC12808127 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature