Common neural dysfunction in psychiatric disorders: Insights from a meta-analysis of resting-state fMRI studies.

ABSTRACT: A central challenge in psychiatry is the need for improved diagnostic accuracy and treatment efficacy. Recent dimensional frameworks like the Research Domain Criteria (RDoC) initiative address this by promoting a transdiagnostic approach to identify shared neural mechanisms across psychiatric disorders. Here, we conducted a transdiagnostic meta-analysis of resting-state fMRI studies that employed amplitude-based measures of spontaneous brain activity-the amplitude of low-frequency fluctuations/fractional ALFF (ALFF/fALFF) and regional homogeneity (ReHo). Our results revealed that patients, compared to healthy controls, exhibited significantly elevated ALFF/fALFF in the lateral orbitofrontal cortex, anterior insula, and caudate, as well as increased ReHo in the ventrolateral prefrontal cort

SUBMITTER: Wang L 

PROVIDER: S-EPMC12808134 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature