Multi-omics analysis reveals hypoxia adaptation mechanisms in an anti-flowing F1 generation of large yellow croaker (Larimichthys crocea).

ABSTRACT: The large yellow croaker (Larimichthys crocea) is a cornerstone of China's mariculture. This study integrates transcriptomic, proteomic, and metabolomic analyses to determine hypoxia adaptation mechanisms in an anti-flowing F1 generation (FDTL) compared with non-selected (FDCL) counterparts under 24-h hypoxic stress (2.0 mg/L dissolved oxygen). FDTL exhibited higher survival (67% vs. 42%). Transcriptomic analysis identified 852 differentially expressed genes, with significant enriched pathways including hypoxia-inducible factor signaling, glycolysis/gluconeogenesis, and IL-17-mediated immunity. Metabolomic profiling revealed 463 differential metabolites, predominantly associated with glycerophospholipid metabolism, arachidonic acid metabolism, and VEGF signaling. Proteomic screening detect

SUBMITTER: Li B 

PROVIDER: S-EPMC12808241 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature