Erythrocytosis and thromboembolic risks associated with SGLT2 inhibitors in type 2 diabetes.

ABSTRACT: This study aimed to determine if sodium-glucose co-transporter-2 inhibitors (SGLT2i) use in diabetic patients leads to erythrocytosis and increases the incidence of arterial and venous thrombosis events. This is a retrospective cohort study using records from over 50 U.S. healthcare organizations. Adults with type 2 diabetes who received SGLT2i therapy were compared to those on glucagon-like peptide-1 receptor agonists (GLP1RA) or dipeptidyl peptidase-4 inhibitors (DPP4i). The primary outcome was the risk of erythrocytosis, defined by elevated hemoglobin and hematocrit levels. Secondary outcomes included arterial and venous thromboembolic events. Propensity score matching was applied to balance baseline characteristics, and Cox proportional hazards regression models were used to estimate h

SUBMITTER: Chen YH 

PROVIDER: S-EPMC12808242 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature