Low maternal pertussis protection and quantified infant risk: supporting maternal Tdap vaccination in China.

ABSTRACT:

Background

Pertussis remains a significant threat to infants, particularly in settings like China, where maternal tetanus-diphtheria-acellular pertussis (Tdap) vaccination is not part of the National Immunization Program, and data on maternal pertussis immunity are limited. This study aimed to assess the seroprevalence of protective pertussis toxin (PT) IgG antibodies in pregnant women and quantify the potential risk of infant pertussis under varying epidemiological scenarios.

Methods

A cross-sectional serosurvey was conducted among 1,205 pregnant women in Jiangsu Province, China, from January to December 2024. Serum anti-PT IgG concentrations were measured using ELISA, with a protective threshold defined as ≥40 IU/mL. A scenario-based risk model (P_infant =

SUBMITTER: Wang W 

PROVIDER: S-EPMC12808340 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature