Gut microbiota and traumatic brain injury: insights from an antibiotic-free cohort.

ABSTRACT:

Introduction

Traumatic brain injury (TBI) is a major global health concern, leading to persistent neurological deficits and systemic complications. While animal studies have shown the association between TBI and the gut microbiota, human evidence, particularly in the early post-injury period, remains scarce.

Methods

In this study, we profiled the gut microbiota of TBI patients within 8 days of hospitalization using 16S rRNA sequencing, integrating clinical metadata and excluding individuals who had received antibiotics within the preceding month.

Results

Although alpha diversity remained similar between groups, beta diversity was significantly altered in TBI patients relative to healthy controls, accompanied by increased inter-individual variability. Differential abun

SUBMITTER: Wu H 

PROVIDER: S-EPMC12808345 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature