Efficacy and safety of calcineurin inhibitor therapy in lupus nephritis: a systematic review and network meta-analysis.

ABSTRACT:

Introduction

The aim of this study is to compare the efficacy and safety of calcineurin inhibitors in the treatment of lupus nephritis.

Methods

We systematically searched several electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) and the clinical trial registry ClinicalTrials.gov from their inception to March 1, 2025. Our study included randomized controlled trials that enrolled adult lupus nephritis patients receiving calcineurin inhibitors. The outcomes included renal remission rate and incidence of adverse reactions. The network meta-analysis was performed using Stata 14.0.

Results

Sixteen randomized controlled trials (with a total of 1994 patients) met the inclusion criteria. Regarding total remission, voclosporin-based triple therapy (myc

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12808350 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature