VHH-based CAR-T cells targeting Claudin 18.2 show high efficacy in pancreatic cancer models.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, with a 5-year survival rate below 10%, largely due to late-stage diagnosis and the limited effectiveness of conventional therapies such as surgery, chemotherapy, and radiation. Claudin 18.2 (CLDN18.2)has emerged as a promising target for PDAC. While single-chain variable fragment (scFv)-based CAR-T cells targeting CLDN18.2 have demonstrated therapeutic potential, CAR-T cells engineered with variable heavy-chain-only domains (VHH) exhibit superior efficacy, highlighting the advantages of VHH-based constructs in targeting this antigen. However, the therapeutic efficacy of anti-CLDN18.2 VHH-CAR-T cells remains to be fully elucidated, as previous studies have not comprehensively characterized in

SUBMITTER: Xing Y 

PROVIDER: S-EPMC12808354 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature