Cerebrospinal fluid metabolomic signatures in paediatric MOGAD and POMS.

ABSTRACT:

Introduction

Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) and paediatric-onset multiple sclerosis (POMS) are acquired demyelinating syndromes (ADSs) that are increasingly recognised in paediatric care. They share clinical and magnetic resonance imaging (MRI) features, but they differ in prognosis and management, as POMS is a chronic inflammatory neurodegenerative disorder, whereas MOGAD is not. Early POMS diagnosis is essential to limit disability accumulation. Thus, early identification of these syndromes is key to their adequate management and family counselling and improving the outcome. Cerebrospinal fluid (CSF) biochemistry and cell count, oligoclonal band, IgG index, and serum MOG antibodies, together with brain and spine MRI, are the most val

SUBMITTER: De Gaspari P 

PROVIDER: S-EPMC12808355 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature