Paracetamol or ibuprofen? A pilot study comparing rescue therapy for PDA in preterm infants within the first month.

ABSTRACT:

Aims and objectives

To evaluate a study design aimed to assess the effectiveness and safety of IV paracetamol compared to IV ibuprofen for rescue treatment of clinically and hsPDA in preterm infants.

Setting

This pilot randomised controlled trial was conducted in the regional neonatal intensive care unit in Manchester, UK, between September 2021 and August 2023.

Patients and methods

The study recruited preterm infants (gestational age <32 weeks or birth weight <1,500 g) diagnosed with hsPDA via echocardiogram and presenting with signs and symptoms of PDA. Participants were randomised to receive either paracetamol or ibuprofen within the first 28 days of life. The primary outcome was closure or reduction to non-hsPDA, while secondary outcomes included the incidence of

SUBMITTER: Mukherjee A 

PROVIDER: S-EPMC12808359 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature