Effects of modified Soyo-san (Xiao-yao-san, Shoyo-san) combined with antidepressants on post-stroke depression and functional recovery: a systematic review and meta-analysis.

ABSTRACT:

Background

Over one-third of stroke survivors experience Post Stroke Depression. Conventional antidepressants are effective but have adverse effects. Soyo-san is an herbal medicine used to treat neuropsychiatric diseases that may exert antidepressant effects with fewer adverse effects. However, there is insufficient evidence synthesizing existing Randomized Controlled Trials to provide comprehensive guidance on the effectiveness and safety of combination treatment with Soyo-san.

Purpose

We evaluated the additional benefits and safety of combining Soyo-san with conventional antidepressants for treating Post Stroke Depression through a systematic review and meta-analysis.

Methods

A comprehensive search of seven databases was conducted on October 10, 2024, followed by st

SUBMITTER: Bak J 

PROVIDER: S-EPMC12808369 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature