The neoadjuvant esophageal score: a prognostic tool for predicting survival and postoperative complications in esophageal squamous cell carcinoma.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) remains a major global health challenge, and reliable prognostic markers. We developed and validated the Neoadjuvant Esophageal (NAE) score, derived from treatment response, to predict overall survival (OS) and postoperative complications in locally advanced ESCC.

Methods

We retrospectively analyzed 411 patients with ESCC from four hospitals who underwent esophagectomy following neoadjuvant therapy between July 2013 and November 2020. Patients were stratified into low-, intermediate-, and high-score groups. OS was assessed using Kaplan-Meier and Cox regression analyses, and predictive models were constructed with nomograms. Model performance was evaluated using concordance index (C-index), ROC curves, calibration plots, an

SUBMITTER: Chen H 

PROVIDER: S-EPMC12808431 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature