Neoantigen immune responses in healthy volunteers: insights from multiple integrated keyhole limpet hemocyanin challenge studies on repeated immunization and response covariates.

ABSTRACT:

Introduction

Investigational immunomodulatory drugs are often initially investigated in healthy volunteers, which lack drug-target engagement biomarkers, hampering evaluation of pharmacodynamic effects. A model such as the Keyhole Limpet Hemocyanin (KLH) neoantigen challenge induces a well-controlled adaptive immune response and can be used to study pharmacodynamic effects in healthy volunteers. To increase our understanding of sources of variability in KLH-induced responses, we integrated KLH data from multiple studies executed at our research institute and investigated the contribution of covariates to KLH challenge responses.

Methods

We performed a pooled analysis of seven KLH trials with standardized methodology and design. Included trials immunized participants with KLH

SUBMITTER: Ronner MN 

PROVIDER: S-EPMC12808451 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature