A comparative study of anticoagulation combined with different catheter-directed thrombolysis strategies (urokinase catheter-directed vs. alteplase infusion) in the treatment of intermediate-risk pulmonary embolism.

ABSTRACT:

Objective

To compare the clinical efficacy and safety of anticoagulation combined with catheter-directed urokinase (UK) thrombolysis vs. anticoagulation combined with catheter-directed alteplase (rt-PA) infusion thrombolysis in patients with intermediate-risk acute pulmonary embolism (APE).

Methods

A retrospective analysis was conducted on intermediate-risk APE patients treated at our center between June 2022 and May 2025, all of whom received anticoagulation combined with catheter-directed thrombolysis. The UK group (n = 56) received continuous UK infusion via pulmonary artery catheter (400,000-500,000 IU/day for 2-3 days), while the rt-PA group (n = 23) received intraprocedural rt-PA infusion (20 mg/30 min). Changes in cardiac troponin I (cTnI), N-terminal pr

SUBMITTER: Huang J 

PROVIDER: S-EPMC12808480 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature