Redox-modulating macrophage biohybrid nanoplatform for targeted RIPK1-PANoptosome suppression in ischemic stroke.

ABSTRACT: Disruption of redox homeostasis during reperfusion triggers a complex and dynamic neuroinflammatory cascade in ischemic stroke, posing a major barrier to precision therapy. Although cellular therapies have emerged as a promising strategy, their clinical translation is hindered by the lack of tools capable of simultaneously tracking cell delivery and modulating pathological redox imbalance in vivo. Here, we report an MRI-trackable engineered macrophage-derived biohybrid nanoplatform that integrates the inflammation-homing capacity of macrophages, the imaging functionality of ultrasmall superparamagnetic iron oxide nanoparticles, and the redox-regulating activity of 2,2,6,6-tetramethylpiperidine-1-oxyl-doped lipids to restore local redox homeostasis. Leveraging their innate tropism toward in

SUBMITTER: Jiang W 

PROVIDER: S-EPMC12808503 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature