Biological functions of tsRNAs and research advances in human disease.

ABSTRACT: tsRNAs (tRNA-derived small RNAs) are a class of noncoding small RNAs generated by nuclease-specific cleavage of mature tRNAs or their precursors. Since their functional discovery in 2009, tsRNAs have emerged as a research hotspot in molecular biology and medicine because of their unique generation mechanism, tissue-specific expression patterns, and diverse regulatory functions. Compared with traditional non-coding RNAs (such as miRNAs and lncRNAs), tsRNAs exhibit distinct biological activities in stress responses, translational regulation, and epigenetic modifications and are closely associated with the onset and progression of various human diseases. This systematic review covers the discovery history, classification characteristics, primary biological functions, and action mechanisms of

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12808512 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature