SERPINA3 facilitates malignant progression and remodels tumor immune microenvironment in glioma.

ABSTRACT: Glioblastoma (GBM) have high aggression and immunosuppression characteristics, with treatment limitation and poor clinical prognosis. Glioma-associated macrophages and microglia (GAMs) constitute the majority immune cells in the tumor microenvironment (TME). Differential molecular characteristics in GBM are related to the poor prognosis and result in therapeutic resistance. Previous research revealed that elevated SERPINA3 expression portends a dismal prognosis for glioma patients. However, the relationship between SERPINA3 and glioma malignant progression, as well as its association with GAMs infiltration, remains unclear. In this study, we explored SERPINA3 levels in different grade glioma tissues and its correlation with GAMs markers. We found that an upregulated of SERPINA3 protein exp

SUBMITTER: Wen W 

PROVIDER: S-EPMC12808515 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature