Mitigating psychological stress-induced cardiac injury: The impact of CB2R agonists on endoplasmic reticulum stress and mitophagy.

ABSTRACT:

Background

Psychological stress is a recognized contributor to cardiac injury and disease; however, the molecular mechanisms underlying this relationship remain incompletely understood, and effective therapeutic strategies are still limited.

Materials and methods

DEGs were identified from our sequencing data and GEO datasets, intersected with ER stress/mitophagy-related genes, and then prioritized by machine-learning and network analyses; pathway activity, immune signatures, molecular subtypes, and miRNA-mRNA interactions (DIANA-TarBase) were further characterized and experimentally validated.

Results

In cardiac injury induced by psychological stress, 38 differentially expressed ER stress- and mitophagy-related genes were identified. Through methods such as LASSO regr

SUBMITTER: Ma C 

PROVIDER: S-EPMC12808523 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature