Gut hormone signaling drives sex differences in metabolism and behavior.

ABSTRACT: Males and females have different physiological and reproductive demands and consequently exhibit widespread differences in metabolism and behavior. One of the most consistent differences across animals is that females store more body fat than males, a metabolic trait conserved from flies to humans. Given the central role of gut hormones in energy balance, we asked whether gut endocrine signaling underlies these sex differences. We therefore performed a multidimensional screen of enteroendocrine cell (EEC)-derived signaling across a broad panel of metabolic and behavioral traits in male and female Drosophila. Here, we uncover extensive sex-biased roles for EEC-derived signals - many of which are conserved in mammals - in energy storage, stress resistance, feeding, and sleep. We find that EE

SUBMITTER: Kubrak O 

PROVIDER: S-EPMC12808592 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature