Integrative severity scale for diabetic macular atrophy and ischemia using structural OCT and OCT angiography.

ABSTRACT: We investigated the characteristics of neurovascular degeneration in diabetic retinopathy (DR) using optical coherence tomography (OCT) and OCT angiography (OCTA). En-face 3 × 3 mm OCTA images were obtained from 327 eyes of DR patients without macular edema. Nonperfusion squares (NPSs) were defined as 15 × 15-pixel regions lacking vascular signals. Neurovascular parameters were extracted from five subfields of the Early Treatment Diabetic Retinopathy Study grid. High-dimensional data were embedded into a two-dimensional space using Uniform Manifold Approximation and Projection, and clustering revealed three distinct groups: Mild, Intermediate, and Severe. Eyes with central subfield thickness (CST) < 246 μm were classified as having diabetic macular atrophy. The Mild group exhibited lower N

SUBMITTER: Yoshida M 

PROVIDER: S-EPMC12808632 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature