Candida tropicalis culture supernatants modulate Pseudomonas aeruginosa antimicrobial resistance and biofilm formation.

ABSTRACT: Polymicrobial infections involving Pseudomonas aeruginosa (PA) and Candida tropicalis (CT) majorly contribute to persistent infections resulting in challenges to effectively treat chronic wounds, such as diabetic foot ulcers (DFUs). We investigated the interactions between PA and CT, especially on the role of microbial metabolites in modulating biofilm formation, growth dynamics, antimicrobial susceptibility, and gene expression in co-habitants. Using clinical isolates from DFUs, we examined the effects of microbial supernatants on biofilm formation, microbial growth, and resistance to antibiotics and antifungals. Additionally, we assessed the expression of resistance genes (aph(3')-IIb and gyrA) in PA in response to treatment with cell-free CT supernatant. Our findings revealed strain-spe

SUBMITTER: Sachdeva C 

PROVIDER: S-EPMC12808655 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature