Multi-omics analysis reveals the effects of prenatal nutrition on carcass-related tissues in beef cattle.

ABSTRACT: This study evaluated the long-term metabolic effects of prenatal nutrition in Nellore bulls. Pregnant cows (n = 126) received mineral supplementation only (NP), protein-energy supplementation during the last trimester (PP), or supplementation throughout pregnancy (FP). At slaughter, longissimus (muscle and meat) and subcutaneous fat samples from the offspring were collected for transcriptomics and metabolomics analyses. Data were reduced using Weighted Gene Co-expression Network Analysis, followed by functional enrichment, and then integrated via Spearman's correlations and holistic pathway analysis. Distinct molecular patterns emerged across prenatal nutrition treatments, although all groups influenced energy metabolism and cellular processes. The NP group was strongly associated with pro

SUBMITTER: Polizel GHG 

PROVIDER: S-EPMC12808689 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature