Chronic administration of isotretinoin induces depressive- and anxiety-like behaviors by altering the neuroactive ligand-receptor interaction pathway in adolescent mice.

ABSTRACT: Clinical case reports have linked isotretinoin to depressive symptoms. As acne incidence peaks in adolescence, we focused on adolescent exposure. However, prior studies on isotretinoin's effects in adolescents have yielded inconsistent results, and direct mechanistic evidence remains scarce. Here, we analyzed depressive-like behaviors in adolescent mice treated with isotretinoin. Pathological changes in the prefrontal cortex and hippocampus of isotretinoin-treated mice were observed. We characterized the metabolic and gene-expression signatures of the hippocampus and prefrontal cortex in isotretinoin-treated mice using RNA sequencing and untargeted metabolomics. The results show that isotretinoin induced depressive- and anxiety-like behaviors and caused significant pathological changes in

SUBMITTER: Ren Y 

PROVIDER: S-EPMC12808720 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature