Prediction of baseline oral microbiota for clinical classification post Omicron variant of SARS-CoV-2 infection.

ABSTRACT: Oral microbiota is related to the severity and recovery of SARS-CoV-2 infection. This study aims to predict clinical classification after SARS-CoV-2 infection using oral microbiota before infection. Herein, we collected tongue-coating samples before infection and then monitored clinical information after infection. Oral microbiota was detected by MiSeq sequencing. We randomly assigned participants from Zhengzhou into discovery and validation cohorts to develop a predictive model and conducted cross-region verification using Xinyang and Hangzhou cohorts. Sixteen asymptomatic patients (AP), 257 mild patients (MP), 106 common patients (CP), and 7 severe patients (SP) were enrolled. Oral microbiota diversity was decreased in CP versus MP. At genus level, 11 microorganisms, including Rothia and

SUBMITTER: Sun J 

PROVIDER: S-EPMC12808735 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature