EOR-1/PLZF promotes WAH-1/AIF-dependent compartment-specific corpse clearance.

ABSTRACT: Programmed cell death (PCD) is a crucial, evolutionarily conserved process required for development and homeostasis. We previously described a genetically non-canonical apoptotic, highly ordered cell death program called Compartmentalized Cell Elimination (CCE) in the C. elegans morphologically complex tail-spike epithelial cell (TSC). Here, we define a role for the transcription factor EOR-1/PLZF as an important, compartment-specific, regulator of CCE. We identify EOR-1 specifically in the dying cell's own clearance, which can function downstream of CED-3/caspase, which is essential for TSC killing. Whereas prior studies implicate EOR-1 in programmed cell killing, we provide mechanistic detail in a new developmental cell elimination context. Specifically, we find EOR-1/PLZF positively reg

SUBMITTER: Rather N 

PROVIDER: S-EPMC12808754 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature