Association of glycemic variability with oxidative stress and AGE accumulation in type 2 diabetes.

ABSTRACT: Oxidative stress and advanced glycation end products (AGEs) could promote vascular aging in type 2 diabetes mellitus (T2DM), but their relationship with glycemic variability remains unclear. We conducted a cross-sectional study of 68 patients with T2DM who underwent continuous glucose monitoring (CGM). Short-, intermediate-, and long-term glycemic variability were assessed using the % coefficient of variation of glucose (%CV), mean of daily differences (MODD), and HbA1c variability over the prior 2 years, respectively. Oxidative stress was measured by the diacron-reactive oxygen metabolites (d-ROMs) test, and AGE accumulation by skin autofluorescence (SAF). Multivariate analyses identified female sex, %CV, MODD, and nephropathy stage as independent correlates of d-ROMs (adjusted R²

SUBMITTER: Ohara M 

PROVIDER: S-EPMC12808768 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature