Characterization and immunogenicity of nanoparticle vaccines based on Clade 2 and Clade 3 sarbecovirus S2 proteins.

ABSTRACT: The emergence of SARS-CoV-2 and its subsequent variants in addition to the previous SARS-CoV-1 outbreak indicates the importance of developing broadly protective sarbecovirus vaccines. To date, broadly protective vaccines have primarily focused on clade 1 sarbecoviruses including SARS-CoV-2 variants and SARS-like animal viruses. The discovery of clade 2 and clade 3 sarbecoviruses capable of infecting human cells highlights a need to preemptively develop vaccines that can protect against these viruses. Here, we develop stabilized multivalent subunit vaccines from clade 2 and clade 3 sarbecovirus S2 proteins and evaluate their immunogenicity. Clade 2 and clade 3 S2-subunit vaccines elicit cross-reactive antibodies in mice capable of binding to clade 1, 2, and 3 sarbecovirus antigens. Female

SUBMITTER: Halfmann PJ 

PROVIDER: S-EPMC12808796 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature