Upregulation of PPTC7 in brain microvascular endothelial cell aggravates diabetic cognitive dysfunction by impairing PHB2 mediated mitochondrial function.

ABSTRACT: Blood-brain barrier impairment (BBB) is the pathological basis of diabetic cognitive dysfunction. Brain microvascular endothelial cells (BMECs) are one of the most mitochondria-rich cell types within the BBB. Mitochondrial dysfunction in BMECs is defined as a pivotal event in diabetic cognitive dysfunction; however, the underlying mechanisms remain poorly understood. Protein phosphatase targeting COQ7 (PPTC7) was screened from RNA-sequencing analysis and its role in regulating mitochondrial function was in both in vitro and in vivo models. PPTC7 expression was predominantly upregulated in BMECs of type 2 diabetes mellitus mice. Genetic manipulations using short hairpin RNA and endothelial-specific adeno-associated virus were applied to investigate the effects of PPTC7 in diabetic cognitive

SUBMITTER: Yang F 

PROVIDER: S-EPMC12808840 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature