Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance.

ABSTRACT: Hypothalamic neurons expressing either POMC or AGRP sense nutritional state directly and indirectly and transmit these neuropeptide signals to other brain centres through the melanocortin 3 and 4 receptors. MC4R is primarily concerned with the control of appetite and energy expenditure while MC3R is more closely related to the control of linear growth and the timing of puberty. The role of MC3R in the long-term control of energy balance and body composition is less clear, particularly in humans. We have undertaken studies in humans, domestic dogs and mice with the goal of clarifying the relative impact of MC3R deficiency on energy balance, growth and sexual development. By studying three large consanguineously enriched cohorts, totalling approximately 300K people, we identified nine indivi

SUBMITTER: Duckett K 

PROVIDER: S-EPMC12808844 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature