Panorama: a database for the oncogenic evaluation of somatic mutations in pan-cancer.

ABSTRACT: Somatic mutations, key alterations in cancer development, exert differential effects across tissues and biological layers, such as transcriptomes, proteomes, and post-translational modifications (PTMs). Although previous pan-cancer studies have characterized the molecular landscape of cancer, the effects of individual somatic mutations across different tissues remain insufficiently explored. Here, we developed Panorama to evaluate the oncogenic potential of single somatic mutations across all cancer types. We collected cancer proteogenomics or multiomics data from over 10 000 individuals across 19 cancer types. Based on five evaluation criteria, we assessed whether a specific mutation affects the abundance of a particular gene's transcriptome, proteome, or phosphoproteome; the tumor microe

SUBMITTER: Park SJ 

PROVIDER: S-EPMC12808847 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature