Fluoride and Neurodevelopmental Hazard Modelling: An Assessment of Concentration-Response Analysis.

ABSTRACT:

Objectives

A National Academies Consensus Study report concluded that the evidence did not support an assessment that fluoride is a neurodevelopmental hazard. However, some researchers have undertaken benchmark dose modelling to determine a safe fluoride concentration level in water. Therefore, the suitability of the data for modelling fluoride concentration in urine and water and cognition response using standard criteria was assessed.

Methods

Data quality was evaluated using a standard tool. A random-effects meta-analysis of standardised mean difference (SMD) and regression coefficients was conducted to assess effect sizes and heterogeneity. The Environmental Protection Agency (EPA) benchmark dose modelling was utilised to determine the association between fluoride concent

SUBMITTER: Kumar JV 

PROVIDER: S-EPMC12808860 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature