Differential Cortico-Thalamic reorganization in Opioid-Induced hyperalgesia and neuropathic pain male rats.

ABSTRACT: Both opioid use and peripheral nerve injury can lead to hyperalgesia. Whereas in peripheral nerve injury, the central neuroplastic is secondary to sustained peripheral signaling, opioid-induced hyperalgesia (OIH) involves maladaptive alterations in both the peripheral and central nervous systems. However, the precise neurobiological mechanisms underlying these two distinct forms of hyperalgesia remain incompletely understood. In this study, OIH and spared nerve injury (SNI), a model of peripheral nerve injury, were established in male rats to investigate the similarities and differences in brain activity. Resting-state fMRI and mechanical stimulus task-state fMRI were employed to identify the differential brain regions between those two groups. Both resting-state fMRI and task-state fMRI r

SUBMITTER: Cai A 

PROVIDER: S-EPMC12808912 | biostudies-literature | 2026 Jan-Jun

REPOSITORIES: biostudies-literature