Visuospatial dysfunction indicates an increased risk of rapid dementia conversion in Parkinson's disease.

ABSTRACT:

Introduction

The aim of this study was to define cognitive subtypes of early-stage Parkinson's disease (PD) based on temporal evolutionary patterns of domain-specific decline.

Methods

We retrospectively enrolled 474 patients with early-stage PD who underwent detailed neuropsychological testing at initial assessment. Age- and education-specific z-scores from 13 neuropsychological subtests were used to apply Subtype and Stage Inference (SuStaIn) to identify distinct cognitive subtypes. We compared the risk of developing dementia between subtypes.

Results

SuStaIn analysis delineated three pd subtypes with cognitive impairment: Subtype 1 (n = 121) with early verbal memory impairment; Subtype 2 (n = 108) with early visuospatial dysfunction; and Subtype 3 (n = 87) with earl

SUBMITTER: Park CW 

PROVIDER: S-EPMC12808930 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature