From the Liver to Heart in Nonalcoholic Fatty Liver Disease: Single-Cell and Serum Evidence for Cytokeratin 18 in Predicting Cardiovascular Risk.

ABSTRACT:

Background

This study is aimed at measuring the expression of serum cytokeratin 18 (CK18) in patients with nonalcoholic fatty liver disease (NAFLD) and at evaluating its ability to discriminate NAFLD patients with and without coronary heart disease (CHD), thereby elucidating its potential role in reflecting the link between NAFLD and increased cardiovascular involvement.

Methods

A total of 127 patients diagnosed with NAFLD and treated between September 2022 and July 2024 were enrolled in this cross-sectional study. Based on the presence or absence of CHD, they were divided into two subgroups: a CHD-present group (n = 79) and a CHD-absent group (n = 48). In addition, a control group consisting of 100 age-matched and sex-matched healthy individuals undergoing rou

SUBMITTER: Xu H 

PROVIDER: S-EPMC12808931 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature