COMPADRE: Combined pedigree-aware distant relatedness estimation for improved pedigree reconstruction.

ABSTRACT: Designing powerful and unbiased genomic studies requires accurate assessment of familial relatedness even when this information is not captured from participants. Characterization of pairwise degrees of relatedness from participants' genetic data enables reconstruction of pedigrees, and several pedigree reconstruction tools have emerged in the last decade. However, limitations of these tools include high computational burden in large datasets, reliance on external information, reduced accuracy in admixed populations, and most notably, an inability to accurately reconstruct pedigrees when only a subset of family members is represented in the genetic data. To improve pedigree reconstruction in large-scale data and in pedigrees with high proportions of ungenotyped individuals, we have develop

SUBMITTER: Evans GF 

PROVIDER: S-EPMC12808943 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature