A Proteomics Resource Investigating Fibrosis: Proof-of-Concept for Identifying Novel Drug Candidates.

ABSTRACT: Fibrosis is characterised by inappropriate wound healing and the buildup of excessive fibrous connective tissue, in particular within the extracellular matrix (ECM). This can occur in multiple organs, ultimately leading to organ failure. Despite the high burden of fibrosis, treatment options only delay disease progression. Therefore, leveraging publicly available proteomics data, we investigated whether common fibrotic proteins and pathways in different organs could be found, to define potential core changes related to fibrosis. We identified 124 significantly differentially expressed proteins in heart fibrosis, four in early-versus-mild liver fibrosis, 135 in mild-versus-severe liver fibrosis and 160 in early-versus-severe liver fibrosis. Functional annotation of each of these groups of p

SUBMITTER: Devos H 

PROVIDER: S-EPMC12809004 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature