Unraveling the Effects and Characteristics of Proliferating Tumor and Cytotoxic T Cells in Colorectal Cancer.

ABSTRACT:

Purpose

The prognostic role of tumor proliferation in colorectal cancer has been unclear, whereas T-cell proliferation has been associated with favorable outcomes. We investigated characteristics and prognostic significance of proliferating tumor and cytotoxic T cells.

Experimental design

Two independent colorectal cancer cohorts comprising 1,839 patients were analyzed using multiplex IHC for MKI67 (Ki-67), CD8, and CK. Densities and spatial localization of MKI67+ and MKI67- cytotoxic T cells and tumor proliferation rate were assessed via digital image analysis. Single-cell RNA sequencing data from 62 colon cancers were used to characterize proliferating and nonproliferating cells.

Results

High MKI67+ tumor cell percentage was associated with better cancer-specific su

SUBMITTER: Kastinen M 

PROVIDER: S-EPMC12809117 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature