Cross-Linking PEG Microgels with Mesoporous Organosilica Nanoparticles to Engineer Microporous Annealed Particle Scaffold Properties.

ABSTRACT: Microporous annealed particle (MAP) scaffolds composed of cross-linked microgels are emerging as important biomaterials due to their modular design, high porosity, and large surface area, which allow for highly tailored properties, cellular infiltration, nutrient and waste exchange, and improved drug release characteristics. To further expand on these technologies and enhance their modular design, thiolated mesoporous organosilica nanoparticles (ssMSN-SH), which degrade in response to glutathione, were first cross-linked inside of 4-arm poly-(ethylene glycol) maleimide microgels. The microgel size, rheological properties, and payload release characteristics were determined. Hierarchical MAP scaffolds were then created by cross-linking 4-arm poly-(ethylene glycol) maleimide microgels with s

SUBMITTER: Zuidema JM 

PROVIDER: S-EPMC12809308 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature