Preparation and Characterization of Chlorin e6-Conjugated Au Nanoparticles as the Radiosensitizer for Enhanced Radiotherapy.

ABSTRACT: The interaction between ionizing radiation and materials composed of high Z-number elements could be applied to enhance radiotherapy. In this work, we fabricated an ionizing radiation-sensitive nanoplatform by grafting chlorin e6 (Ce6) onto the surface of ultrasmall gold nanoparticles (Au NPs), aiming to enhance the radiation effects induced by different radiation sources. Poly-(ethylene glycol) (PEG) was applied as the shape-controlling agent during the synthesis of Au nanoparticles. The as-prepared Au NPs show excellent monodispersity, with an average hydrodynamic diameter of around 5 nm. U87 and HeLa cell lines were utilized to evaluate the biological properties of the as-prepared Ce6-Au NPs. The Cell Counting Kit-8 (CCK-8) results reveal that the Ce6-Au NPs conjugate can significantly

SUBMITTER: Liu H 

PROVIDER: S-EPMC12809335 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature