ICSH Recommendations for Monocyte Cell Lineage Morphologic Identification, Nomenclature Harmonization, and Utilization as a Biomarker.

ABSTRACT: Monocytes are key components of the Mononuclear Phagocyte System, crucial in immune defense, inflammation, and tissue repair. Accurate identification and classification of monocyte lineage cells are essential for diagnosing both reactive and clonal hematologic disorders. However, morphological criteria and nomenclature inconsistencies have hindered reproducibility, particularly with the rise of automated and AI-driven diagnostic tools. The International Council for Standardization in Haematology (ICSH) Monocyte Working Group (MWG) was convened to establish standardized morphological definitions, harmonize nomenclature for monocytes and their precursors, and evaluate their clinical utility as biomarkers. Data were collected from global laboratories, combined with an extensive literature rev

SUBMITTER: Zini G 

PROVIDER: S-EPMC12809381 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature