A high-copper-content metal-organic framework with potential antibacterial activities.

ABSTRACT: Despite recent significant advancements in antibacterial applications of copper-based metal-organic frameworks (Cu MOFs), the synthesis of a high-copper-content MOF remains elusive. Here we proposed a multi-coordination strategy through a direct solvothermal reaction of Cu ions and formic acid, which yielded a three-dimensional MOF (denoted as Cu-FA) containing 32% Cu. Through single crystal X-ray diffraction analyses, the precise spatial structure of Cu-FA was determined. Two types of Cu⋯O coordination bonds with varying bond energies were found in Cu-FA, enabling a multistage Cu release protocol to balance the antibacterial efficacy and biocompatibility. As a result, Cu-FA presented significant antibacterial activity against Escherichia coli, with an inactivation rate of 99.76%. O

SUBMITTER: Liu B 

PROVIDER: S-EPMC12809385 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature