Ag₂WO₄ nanocatalyst-driven green synthesis of pyrano[2,3-<i>d</i>]pyrimidinones: an integrated experimental, DFT, and cytotoxic investigation.

ABSTRACT: The development of environmentally sustainable routes for synthesizing bioactive heterocycles remains a central objective in contemporary medicinal chemistry. In this work, silver tungstate (Ag₂WO₄) nanoparticles were synthesized and characterized by X-ray diffraction and scanning electron microscopy, confirming their crystalline structure and surface morphology. The prepared nanoparticles served as an efficient heterogeneous nanocatalyst for the one-pot green synthesis of pyrano[2,3-d]pyrimidinone derivatives (2a-2h) in an ethanol-water medium, affording excellent yields under mild conditions and demonstrating high catalytic efficiency with strong alignment to green chemistry principles. Comprehensive in silico analyses, including density functional the

SUBMITTER: Perumal S 

PROVIDER: S-EPMC12809388 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature