Special delivery - extracellular vesicles released by commensal gut bacteria deliver bioactive protein to distal organs.

ABSTRACT: Aim: This study aims to investigate how the gut microbiota communicates with the host via bacterial extracellular vesicles (BEVs), given that direct contact between microbes and the healthy intestinal epithelium is prevented by a sterile mucin gel layer. Understanding these indirect interactions is critical because the specific pathways and mediators of microbiota-host interactions are incompletely understood. Tracking BEVs in vivo however is particularly challenging due to their nanoscale size and complex molecular composition. Methods: To address these challenges, we developed a highly sensitive Nanoluciferase (NanoLuc) system for luminescence-based detection of BEVs produced by the model human commensal bacterium Bacteroides thetaiotaomicron. This approach wa

SUBMITTER: Jones EJ 

PROVIDER: S-EPMC12809395 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature