17,18-epoxyeicosatetraenoic acid ameliorates mRNA-LNP-induced local inflammation by inhibiting neutrophil infiltration.

ABSTRACT: Lipid nanoparticles (LNPs) are a powerful technology for delivering nucleic acids into cells and have greatly contributed to the development of severe acute respiratory syndrome coronavirus 2 mRNA vaccines and nucleic acid-based therapeutics. However, side effects such as pain and swelling at the injection site have been reported after vaccination with severe acute respiratory syndrome coronavirus 2 mRNA, and these are thought to be partly due to LNP-induced inflammation. In this study, we focused on an anti-inflammatory metabolite derived from omega-3 fatty acids and investigated whether it could suppress LNP-induced inflammatory side effects associated with mRNA-LNP vaccination. Intramuscular injection of empty LNPs lacking mRNA elicited inflammatory responses in mice comparable to those

SUBMITTER: Iemitsu K 

PROVIDER: S-EPMC12809493 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature