Bioactivity and Biocompatibility of a Polydopamine-Bridged, BMP-2-Functionalized Multilayer Coating on Stainless Steel for Bone Implant Applications.

ABSTRACT: Implant failure due to poor osteogenesis and bacterial infection remains a major concern, emphasizing the importance of enhancing both the osteogenic and antibacterial activities of implants. This study focuses on using polydopamine (PDA)-bridged bone morphogenetic protein-2 (BMP2) and grafting it onto benzophenone (BP)-photoinitiated 2-methacryloyloxyethyl phosphorylcholine (MPC)-coated stainless steel (SS) to form a functionalized SS substrate (SS-BP-MPC-PDA-BMP2). The PDA bridge layer induced a greater BMP2 immobilization level (6-fold improvement), mitigated burst release, and sustained a controlled release rate (0.44 ng/cm²/day) over a ten-day period. Surface wettability (at a water contact angle of 33°) and smoothness (at a root mean square of 24 nm) were achieved in the B

SUBMITTER: Secario MK 

PROVIDER: S-EPMC12809520 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature