Oral Microbial Diversity is Associated with Biologic Treatment and Metabolic Health Status but not with Disease Activity in Patients with Inflammatory Bowel Disease.

ABSTRACT:

Background

Higher diversity of the oral microbiome has been associated with poorer oral health outcomes in the general population. We aimed to characterize the oral microbiota in patients with inflammatory bowel disease (IBD) and compare this with that of healthy controls (HC). We also sought to examine associations between IBD management and disease control, diet and metabolic disease with oral microbial diversity.

Methods

This prospective case-control study compared participants with IBD in clinical remission with HC. Baseline anthropometry and fasting blood metabolic markers were measured, dietary intake recorded, and oral samples were collected for 16S rRNA gene amplicon sequencing.

Results

There were 57 patients with IBD (Ulcerative colitis (UC) = 26, Crohns Dise

SUBMITTER: Wark G 

PROVIDER: S-EPMC12809532 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature