Molecular mechanisms of disinfectant resistance in <i>Klebsiella pneumoniae</i>.

ABSTRACT:

Objectives

Chemical disinfectants are critical for infection control in healthcare environments and beyond, as exemplified by their vital role during the COVID-19 pandemic. Despite research repeatedly demonstrating that bacteria can develop adaptations that mitigate the efficacy of chemical disinfectants, the underlying molecular mechanisms remain poorly characterized. This study investigates the mechanisms that underpin resistance demonstrated by disinfectant-adapted Klebsiella pneumoniae NCTC 13443 samples.

Methods

Resistant samples have previously undergone long-term in vitro adaptation via serial passage in increasing concentrations of common disinfectants benzalkonium chloride (BAC), didecydimethylammonium chloride (DDAC), polyhexamethylene biguanide (PHMB

SUBMITTER: Noel DJ 

PROVIDER: S-EPMC12809559 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature