Subcortical correlates of developmental language disorder: more than the neostriatum.

ABSTRACT: Developmental language disorder (DLD) is a common neurodevelopmental disorder that affects receptive and expressive language skills. In contrast to the wealth of evidence on acquired language disorders, we understand relatively little about the neural underpinnings of DLD. A recent meta-analysis across different types of structural brain analyses in DLD highlighted consistent anatomical differences in the anterior striatum, with other subcortical structures relatively spared. These findings are consistent with predictions from the procedural circuit deficit hypothesis (PCDH), namely that the anterior neostriatum differs in structure and function in DLD, whereas medial temporal lobe structures are unaffected and may act in a compensatory manner. Here, in a case-control study with a larger s

SUBMITTER: Cler GJ 

PROVIDER: S-EPMC12809564 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature