Predictive <i>N</i>‑Glycan Signatures of Severe Traumatic Brain Injury in Biofluids Using LC-MS/MS.

ABSTRACT: Traumatic brain injury (TBI) poses a significant global health issue, frequently resulting in persistent and even lifelong cognitive and neurological impairments. Despite remarkable advances in biomarker discovery, significant challenges remain in the accurate diagnosis and prognosis of TBI. Glycosylation, an important post-translational modification of proteins and other biomolecules, plays an essential role in neuronal function and neuroinflammation. However, its contribution to the pathogenesis of TBI has been insufficiently investigated. This study examines changes in N-glycosylation patterns in serum and cerebrospinal fluid (CSF) from individuals with severe traumatic brain injury (sTBI) at various time points postinjury. Employing advanced glycomics methodologies and liquid ch

SUBMITTER: Solomon J 

PROVIDER: S-EPMC12809573 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature